Weight Loss Bodybuilding Prohormones Sarms Ibutamoren Mk-677 CAS no. 159752-10-0

MK-677

Basic Information:

Synonym: MK-677;Ibutamoren;L 163191; L163,191; L-163,191; MK0677; MK0677; MK-0677; MK-677; MK677; MK 677;2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide mesylate.
CAS No.: 159752-10-0
MW: 624.776
MF: C27H36N4O5S.CH4O3S
Purity: 99 (HPLC)
Boiling Point : 868.9 °C at 760 mmHg
Flash Point : 479.3 °C
Stability: Store at at 20 °C in dry place until the expiration date.
Apprarance: White powder.
MOQ: 10g
Payment terms:T/T  ,Bitcoin

Introduction:

MK-677 is an orally administrated growth / hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete . In other words, MK-677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6. This GHS (Growth / Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
 

Description:

Ibutamoren (MK-677, L-163,191) is a drug which acts as a potent, orally active growth hormonesecretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.

How MK-677 Works?

Growth hormone pulse intensity can be increased through 4 possible mechanisms:

1. Increasing GHRH (growth hormone releasing hormone) release.
2. Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
3. Reducing somatostatin release (somatostatin turns off GH release).
4. Inhibiting of somatostatin receptor signaling.

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