|Place of Origin:||Wuhan|
|Minimum Order Quantity:||10g|
|Packaging Details:||Discreet ways of packing for customs guaranteed|
|Delivery Time:||Within 12 hours after confirmation of your payment|
|Payment Terms:||T/T, , ,Bitcoin,Paypal|
|Supply Ability:||2000kg Per Month|
|Grade:||Pharmaceutical Grade||Molecular Weight::||606.77|
|Appearance:||White Or Off-white Crystalline Powder||MF:||C32H47F5O3S|
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SGS High Purity Fulvestrant Anti Estrogen Steroids Without Side Effects 129453-61-8
SGS High Purity Fulvestrant Anti Estrogen Steroids CAS 129453-61-8
Boiling Point:674.8 °C at 760 mmHg
You should know:
Fulvestrant is a selective estrogen receptor antagonist, or estrogen receptor down-regulator. It is able to eliminate the action of estrogen in the body by blocking the available estrogen receptors. So therefore unlike aromatase inhibitors it does not prevent aromatization, but rather limits the activity of the estrogen after it is created. As with most aromatase inhibitors and selective estrogen receptor modulators the primary use of fulvestrant is in the treatment of estrogen-dependent breast cancer. This is still what it is predominantly used for medically now.
Fulvestrant Powder Descriptions:
Fulvestrant (Faslodex) is an antagonist of estrogen receptor-α (ERα), a steroid receptor member of the nuclear receptor superfamily of transcription factors, that has been used in the treatment of advanced breast cancer. It is a pure antiestrogen, that is, it has no agonist effects, as distinct from selective estrogen receptor modulators (SERMs) which are capable of context-dependent regulation of the ER.
Fulvestrant injection is used to treat metastatic breast cancer (cancer that has spread) that is hormone-receptor positive in women who have already stopped menstruating (postmenopausal). It is used for women who have breast cancer that has not improved after using other cancer medicines.
Many of the breast cancer tumors will grow when estrogen is available in the body. This medicine blocks the effects of the estrogen hormone in the body. As a result, the amount of estrogen that the tumor is exposed to is reduced, which will limit the growth of the tumor.
Fulvestrant Powder Usages:
Fulvestrant is a selective estrogen receptor degrader (SERD).It is indicated for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy.
Fulvestrant provides effective second-line therapy in metastatic or locally advanced breast cancer for postmenopausal women who relapse or progress after previous endocrine therapy.
Four clinical trials in this setting showed similar efficacy to the other hormonal agents (aromatase inhibitors and tamoxifen) with good tolerability profile. Fulvestrant had a lower incidence of joint disorders.
Fulvestrant Powder Mechanism of Action:
Many breast cancers have estrogen receptors (ER), and the growth of these tumors can be stimulated by estrogen. Fulvestrant is an estrogen receptor antagonist that binds to the estrogen receptor in a competitive manner with affinity comparable to that of estradiol. Fulvestrant downregulates the ER protein in human breast cancer cells.
In a clinical study in postmenopausal women with primary breast cancer treated with single doses of FASLODEX 15-22 days prior to surgery, there was evidence of increasing down regulation of ER with increasing dose.
This was associated with a dose-related decrease in the expression of the progesterone receptor, an estrogen-regulated protein. These effects on the ER pathway were also associated with a decrease in Ki67 labeling index, a marker of cell proliferation.
Fulvestrant Powder Side Effects:
Injection site reactions (pain, swelling, redness), nausea, vomiting, loss of appetite, constipation, diarrhea, upset stomach, dizziness, headache, tiredness, weakness, headache, back pain, joint pain, muscle pain, pain in your arms or legs, other body aches/pains, flushing and sweating (hot flushes/hot flashes), tiredness, cough, trouble sleeping, or trouble breathing.
Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive. Drugs that block the effects of these hormones can slow or stop the growth of the breast cancer cells. Fulvestrant stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cell has.
Fulvestrant Acetate (Faslodex, AstraZeneca) is a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works by down-regulating the estrogen receptor.
Fulvestrant Acetate is a selective estrogen receptor down-regulator (SERD). Fulvestrant is indicated for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. The dosing schedule for fulvestrant remains under investigation in an attempt to optimize its effectiveness.
Packaging & Delivery:
Professional team and sufficient stock.
Fast and discreet shipment can be arranged for customs pass Guaranteed.
Packing pictures and tacking code can be provided within 12 hours after receiving the payment.
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Professional raw powder factory in China, all powders are factory directly supplying. Have over 10 years’ honour.
We exported to all over the world such as Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and so on, over 100kgs each month.
Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
Our products and services will focus on the largest customer demand,We hold the greatest enthusiasm and sincere cooperation with each customer.
Discount would be given when you place large order.
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1. Pinpoint what you need, specification, CAS No., assay, grade.
2. Ensure the discreet parcel and offer the suitable shipping method for reference.
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