Place of Origin: | Wuhan |
Brand Name: | Excellentbiotech |
Certification: | SGS,ISO9001,UKAS,GMP |
Model Number: | 330784-47-9 |
Minimum Order Quantity: | 10g |
---|---|
Price: | Negotiable |
Packaging Details: | Discreet ways of packing for customs guaranteed |
Delivery Time: | Within 8 hours after payment |
Payment Terms: | T/T, , ,Bitcoin,Paypal |
Supply Ability: | 2000kg Per Month |
Name: | Avanafil | CAS: | 330784-47-9 |
---|---|---|---|
MF: | C23H26ClN7O3 | MW: | 483.9506 |
Character: | White To Off-White Cyrstalline Powder | Usage: | Steroid Hormone |
High Light: | sex steroid hormone,male enhancement steroids |
Safety and High Purity Avanafil 330784-47-9 Sex Enhancing Drugs Steroid Hormone Powder
1. Product Details:
Synonyms: (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine;4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;Avanafil;Avanafil (usan/inn);D03217;4-[[(3-Chloro-4-Methoxyphenyl)Methyl] aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;(S)-4-((3-Chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide
Assay: 99% min.
CAS: 330784-47-9
Molecular Formula:C23H26ClN7O3
Molecular Weight:483.9506
Character: White to Off-White Cyrstalline Powder
Usage: Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.
Categories: Active Pharmaceutical Ingredients; Cnbio; Erectile Dysfunction; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; API's.
Certificates:SGS,ISO 9001, GMP
MOQ:10 gram
Provide Samples: Yes.
Delivery time: Within 12 hours upon receipt of payment
Payment method: T/T,, , bitcoins, bank transfer
Skype: steroidlab
Price: Factory price(Negociable)
Packing: Discreet and Disguised packing to pass the customs.
Delivery methods: EMS, DHL, TNT, FedEx, UPS,etc door to door.
Standard: GMP Enterprise standard.
The min. order is 10 grams.
Export Markets:Global
Storage: Shading, Confined Preservation
Usage:Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor
2. Description:
Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012 [1] and by EMA on June 21, 2013.[2] Avanafil is known by the trademark names and was developed by Vivus Inc. In July 2013 Vivus announced partnership with Menarini Group, which will commercialise and promote in over 40 European countries plus Australia and New Zealand.[3] Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina.Other similar drugs are tadalafil and vardenafil.
3. Usage:
It is a development of the phosphodiesterase type 5 inhibitors, for the treatment of male sexual dysfunction, at present in the America, EU and Japan have completed phase II clinical trials, phase III clinical trials will start. The product is composed of Japanese Tanabe Pharma Company and VIVUS company development. In addition to oral dosage forms, VIVUS company is also developing Avanafil urethral administration, for not responding to oral dosage forms of patients.
Avanafil is a potent, highly selective phosphodiesterase 5 inhibitor, in vitro experiments showed that the selectivity of phosphodiesterase 5 stronger than . The compound dear compliance weak against other phosphodiesterase, and effect of adenosine receptor decreased, suggesting that the cardiovascular effects of avanafil should be weaker than .
Pre clinical study showed that avanafil and organic nitrate drugs taken in combination to reduce its on blood pressure was significantly weaker than and nitrate drugs with clothes. Moreover, avanafil inhibition of phosphodiesterase 6 is very weak, the relevant visual disturbance suppression may the enzyme phosphodiesterase 5 inhibitor induced and other.
4. COA
Test Items | Specification | Test Results |
Description | White or almost white crystalline powder | White crystalline powder |
Melting Point | 191.0~193.0ºC | 192ºC |
Loss of drying | ≤1.0% | 0.5% |
Heavy Metal | ≤20ppm | 15ppm |
TLC | Only one spot | Only one spot |
Assay | ≥99.5% | 99.91% |
5. Application:
The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about 30-45 minutes.About two-thirds of the participants were able to engage in sexual activity within 15 minutes.
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6.Packaging&Delivery
1).We promise to provide high purity of raw steroid powders & semi-finished liquid;
2).We have professional packing team always find new ways to make the disguised package for custom pass guaranteed;
3).We have Long term cooperation Express courier companies to delivery your goods safe and speedy door to door;
4).We always thinking more for customers, 24/7 good after-sale service to solve the problems at any time;
5).Resend policy once the parcel delivery failed by accident.
Contact Person: lisa
Tel: +8613798562250
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