Arimidex CAS 120511-73-1 Third-generation Aromatase Inhibitor Anastrozole Raw Powder

Introduction:
Anastrozole is a non-steroidal aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer can be increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozole works by inhibiting the synthesis of estrogen.

The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial was an international randomised controlled trial of 9366 women with localized breast cancer who received either anastrozole, tamoxifen, or both for five years, followed by five years of follow-up. After more than 5 years the group that received anastrozole had significantly better clinical results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer, which is estrogen receptor (ER) positive. Another study found that the risk of recurrence was reduced 40%, but was associated with an increased risk of bone fractures. The study concluded that ER positive patients benefited from switching from tamoxifen to anastrozole in patients who have completed 2 years' adjuvant tamoxifen. A more recent trial found that anastrozole significantly reduced the incidence of breast cancer in postmenopausal women relative to placebo, and while there were side effects related to estrogen deprivation observed, the researchers concluded that this was probably not related to the treatment.

Description:
The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimi.dex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimi.dex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.

Purpose:
Third-generation aromatase inhibitors. For the treatment of postmenopausal patients with advanced breast cancer. A potent selective triazole aromatase inhibitor, which inhibits the biosynthesis of estrogen by inhibiting the aromatase enzyme C-450, which is a major factor in stimulating the growth of breast cancer cells. Treatment of breast cancer, especially for those with hormonal adjuvant therapy after the recurrence of postmenopausal women with advanced breast cancer.


Effect:
Arimidex can be referred to as an aromatase inhibitor which helps prevent estrogen production in females. Research has shown that the estrogen hormone is responsible for the creation of breast cancer tumors in women. Arimidex is the drug administered to intercept the enzyme aromatase, which is a substance that assists the body tissues in producing estrogen. Arimidex is a popular drug in the battle against breast cancer. It is by and large, a hormonal treatment which can prevent the recurrence of breast cancer. Arimidex, also known as Anastrozole is not a steroid.

Arimidex is known to have diminished estrogen way too much in some patients. This is why blood tests or salivary tests are recommended after a week of usage to determine whether the dosage is appropriate.

Arimidex tends to work quite differently than the traditional anti-estrogens. Anti-estrogens like Clomid or Nolvadex tend to intercept estrogen receptors in certain tissues while activating them in others. Meanwhile, Arimidex directly intercepts the enzyme aromatase. When a patient has been recommended the use of Arimidex, Clomid use along with is unnecessary. Doing so may have some benefits.

Arimidex is generally used for all stages and forms of breast cancer which are classified to be estrogen receptor positive. In case the patient has estrogen receptor negative or triple negative cancer, the usage of Arimidex is unlikely to help.


How does Arimidex work ?
Arimidex generally works by blocking the aromatoze enzymes, facilitating the decrease in the production of estrogen in the human body. With the decrease in production of Arimidex, the risk of exposure to breast cancer is eliminated. This procedure of treating breast cancer is known as hormonal therapy.


Dosage:
Dosages of arimidex will vary from person to person. This is why blood work is essential to finding the perfect balance. One should start out at half a mg every other day and adjust as needed for the cycle. Some AAS users will not use an AI at first but they will have it on hand just in case. This isn’t always a good idea, as once you start noticing gyno or excessive water weight it could be too late to reverse. Since AAS will continue building in the body and aromatize (steroids turning into estrogen), taking arimidex at this point would be like trying to stop a car already in motion.

General dosages for men: 0.5mgs per day or every other day. Remember, it’s steroid dose dependent.