Top Grade Gabapentin CAS 60142-96-3 , 99.94% Purity Antiepileptic Popular Product

Gabapentin

Basic Details:

Description:

Gabapentin is a new antiepileptic drug. It has broad application prospects in chronic pain syndrome, especially neuropathic pain.

Compared with amitriptyline, gabapentin is more effective and has less side effects. A single oral dose of gabapentin 120m per day can significantly reduce the amount of morphine and active pain after radical mastectomy without obvious side effects. Gabapentin can interrupt the whole process leading to neuropathic pain, rather than an intermediate link.

Indications: Gabapentin can be used for the treatment or auxiliary treatment of post zoster neuralgia, diabetes neuralgia, cancer neuralgia, trigeminal neuralgia, neuralgia caused by multiple sclerosis, complex local pain syndrome, post herpetic neuralgia and other neuralgia.

Compared With Pregabalin:

Both gabapentin and pregabalin are antiepileptic drugs, and their chemical structure and anti-epileptic mechanism are similar, but they are not the same drug. The anti-epileptic mechanism of gabapentin and pregabalin is to act on the P/Q calcium channel. They can block the voltage-dependent calcium channel, inhibit the calcium influx, reduce the release of neurotransmitter, and play an anti-epileptic role. However, pregabalin can also regulate the release of other neurotransmitters, such as glutamate, norepinephrine, substance P. Gabapentin is a synthetic cyclic amino acid γ- Derivatives of aminobutyric acid. It is mainly used for intractable partial seizures, but also widely used for various neuropathic pain, such as post herpetic neuropathy, diabetes neuropathy, post stroke central pain, etc. Pregabalin is a P/Q type calcium channel regulator, which is mainly used for localized partial seizures, and can also be used for peripheral neuropathic pain, such as postherpetic neuralgia.

Usage:

For the treatment of neuralgia, the recommended dose is 300mg at the beginning, three times a day, and the dose can be gradually increased as needed. The maximum dose is 3600mg per day, but not more than 4200mg.

Side Effects:

Gabapentin has good tolerance and few serious side effects. The most common side effects are drowsiness, dizziness and fatigue. Especially suitable for thousands of elderly patients or patients with abnormal liver function.