Anti Estrogen Raw Powder Clomiphene Citrate , Treating Infertility CAS 50-41-9 Clomid

                                   Clomifene Citrate

Basic Details:

History:

A team at William S. Merrell Chemical Company led by Frank Palopoli synthesized clomifene in 1956; after its biological activity was confirmed a patent was filed and issued in November 1959. Scientists at Merrell had previously synthesized chlorotrianisene and ethamoxytriphetol.

Clinical studies were conducted under an Investigational New Drug Application; it was third drug for which an IND had been filed under the 1962 Kefauver Harris Amendment to the Federal Food, Drug, and Cosmetic Act that had been been passed in response to the thalidomide tragedy. It was approved for marketing in 1967 under the brand name Clomid. It was first used to treat cases of oligomenorrhea but was expanded to include treatment of anovulation when women undergoing treatment had higher than expected rates of pregnancy.

The drug is widely considered to have been a revolution in the treatment of female infertility, the beginning of the modern era of assisted reproductive technology, and the beginning of what in the words of Eli Y. Adashi, was "the onset of the US multiple births epidemic".

Description:

Clomiphene Citrate or Clomid is a powerfully effective anti-estrogen officially classified as a Selective Estrogen Receptor Modulator (SERM). In many ways, it is very similar to another popular SERM in Nolvadex (Tamoxifen Citrate). Clomid first gained worldwide attention in the early 1970’s as a strong fertility aid and is still used for that purpose today. It is also one of the most commonly used SERM’s by anabolic steroid users. No, it is not an anabolic steroid but can be used to combat estrogenic side effects sometimes caused by anabolic steroids. It can also be used as a Post Cycle Therapy (PCT) medication in order to stimulate suppressed testosterone production due to anabolic steroid use. PCT use of Clomid is the most common purpose and most beneficial point of use for the anabolic steroid user.

Applications:

1. Clomifene for Treatment of Infertility:
Clomifene is useful in those who are infertile due to anovulation or oligoovulation.Evidence is lacking for the use of clomifene in those who are infertile without a known reason.In such cases, studies have observed a clinical pregnancy rate 5.6% per cycle with clomifene treatment vs. 1.3%–4.2% per cycle without treatment.

Clomifene has also been used with other assisted reproductive technology to increase success rates of these other modalities.

2. Clomifene Help increase of testosterone:

Medical treatment is most often prescribed for men who have hormonal abnormalities. For example, some men with low sperm counts have low levels of the primary male hormone, testosterone. Although the logical approach might be to give a man with a low testosterone level supplemental testosterone, in fact, that is the wrong thing to do.the same clomiphene citrate we give to women to help them ovulate regularly. Clomiphene works essentially the same way in both women and men; in women, it binds to receptors in the brain (specifically the hypothalamus and the pituitary gland) to increase the production of follicle stimulating hormone (FSH) and luteinizing hormone (LH). These hormones act on the ovarian follicles to induce egg development and ovulation. In men, the increase in FSH leads to an increase in sperm production, whereas the increase in LH leads to an increase in testosterone production.

3. clomid's usage for Bodybuilders:

Male bodybuilders who cycle anabolic androgenic steroids (AAS) have found that the same mechanisms of increased LH (luteinizing hormone) can be taken advantage of to increase total testosterone levels. This is why clomid is popular in post cycle therapy (PCT) among those who cycle anabolic steroids. Since clomid has ability to bind to the estrogen receptors, much like nolvadex, in male users who run estrogenic compounds such as testosterone, dianabol, and deca durabolin, it can be used as gynecomastia treatment (anti-gyno). However, clomid is a fairly weak anti-gyno aid, and is rarely used for that purpose.

Clomid Contradictions:

1. Do not use clomiphene if you are already pregnant;
2. Do not use clomiphene if you have: liver disease, abnormal vaginal bleeding, an uncontrolled adrenal gland or thyroid disorder, an ovarian cyst;
3. Do not use clomiphene if there is a tumor of your pituitary gland;
4. Do not use clomiphene if an untreated or uncontrolled problem with your thyroid or adrenal gland.

Dosage:

50 mg orally once a day for 5 days. Therapy should be initiated on or near the 5th day of the menstrual cycle, but may be started at any time in patients without recent uterine bleeding.

If ovulation occurs and pregnancy is not achieved, up to 2 additional courses of clomiphene 50 mg orally once a day for 5 days may be administered. Each subsequent course may be started as early as 30 days after the previous course and after pregnancy has been excluded.

Most patients ovulate following the first course of therapy. However, if the patient fails to ovulate, a second course of 100 mg/day for 5 days may be given as early as 30 days following the initial course. A third course of 100 mg/day for 5 days may be given after 30 days, if necessary.

Treatments beyond three cycles of clomiphene, dosages greater than 100 mg once a day, and/or course durations beyond 5 days are not recommended by the manufacturer. However, successful pregnancies and term deliveries have been reported in women receiving up to 200 mg/day for 5 days, or extended 10-day course of therapy, or consecutive cycles of treatment beyond the 3 recommended by the manufacturer.