99.6 High Purity Body Building Powder Hydrochloride

99.6 High Purity Body Building Powder Hydrochloride

CAS 129938-20-1 hydrochloride

Product Name: hydrochloride
Alias: ,Dapoxe, Dapoxeti ,hy, HCl
CAS No: 129938-20-1 or 119356-77-3
Molecular Formula:C21H24ClNO
Molecular weight:341.88
Purity: 98%
Appearance: White crystalline powder
Grade:Pharmaceutical Grade

Unfortunately, the efficacy and safety of (30 mg and 60 mg on-demand) has never been comprehensively studied in men with PE. Most data derived from clinical studies in men with PE are available. The objective of this study was to not only evaluate the efficacy and safety of when used at either 30 mg or 60 mg as compared with the placebo as an oral on-demand treatment in men with PE in routine clinical practice by performing a meta-analytic synthesis of studies, but also to assess whether there are differences in efficacy and safety for PE treatment using either 30 mg or 60 mg .

Treat male premature ejaculation and erectile dysfunction.

, marketed as (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) for men between 18-64 years old. works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, so as to delay consequence ejaculation. As a member of selective serotonin reuptake inhibitor (SSRI) family, was initially created as an antidepressant. However, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its immediate response makes it suitable for the treatment of PE but not as an antidepressant.

hydrochloride, a fast-acting serotonin reuptake transporter inhibitor, is generally prescribed for the treatment and management of premature ejaculation and erectile dysfunction in adult male.Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT about 2-9 time in comparison of three to eight times when is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence, an increasing adverse effects such as decreasing sexual libido and causing erectile dysfunction. , on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.

Pharmacodynamics

hydrochloride is a selective serotonin reuptake inhibitor. The physiology of ejaculation primarily depends on serotonin and dopamine receptors including 5-HT1a and 5-HT2c. hydrochloride prevents the reuptake of serotonin transporter. The drug binds with the reuptake transporters of norepinephrine and dopamine and inhibits the reuptake.

Dosage

For premature ejaculation and erectile dysfunctions (Adults):The recommended adult dose of hydrochloride is 30 - 60 mg/day. The maximum dose should not exceed 100 mg/day. Take hydrochloride at least two hours before sexual intercourse to achieve maximum treatment benefits.