NPP Nandrolone Phenylpropionate Raw Powder Bodybuilding Anabolic Steroid Durabolin Powder CAS 62-90-8

Nandrolone Phenylpropionate

Specifications:
Product name: Nandrolone Phenylpropionate
Synonyms: Durabolin ; NPP
CAS No.: 62-90-8
Standard: USP35
Refrigeration save: Room temperature more than 20 Celsius degree to agglomerate,or so 30 Celsius degree into a liquid

Describe:

Nandrolone phenylpropionate is an injectable form of the anabolic steroid nandrolone. The properties of this drug are very similar to those of nandrolone decanoate. The main difference between these two preparations is how quickly nandrolone is released into the bloodstream. While nandrolone decanoate provides about 3 weeks of nandrolone release in the injected area, nandrolone phenylpropionate provides only one week. Therefore, in clinical situations, nandrolone decanoate can be injected every 2 or 3 weeks, while nandrolone phenylpropionate should be injected once a week. On the other hand, the two drugs are practically interchangeable. Like nandrolone decanoate, nandrolone phenylpropionate is a valuable drug that enables athletes and bodybuilders to improve muscle strength and lean muscle mass without significant estrogenic or androgenic side effects.

History:

Nandrolone phenylpropionate first appeared in 1957. It soon became a prescription drug, marketed under the brand name nandrolone phenylpropionate by international pharmaceutical giant Organon (now Merck/MSD). When first introduced in the United States, nandrolone phenylpropionate was used for preoperative and postoperative sperm quality preservation, osteoporosis, advanced breast cancer, convalescent or disease-induced weight loss, geriatric disease (general weakness and weakness), burns, Adjunctive treatment of severe trauma, ulcers, anemia and growth retardation in children.

In the 1970s, the FDA began modifying the drug's use, and its use soon became significantly less. After a while, the drug was used primarily for the treatment of advanced metastatic breast cancer and as an adjuvant therapy for postmenopausal osteoporosis in older adults.

Nandrolone phenylpropionate has been the focus of Organon's marketing efforts for less than a decade. When nandrolone decanoate was introduced in the 1960s, the short-acting drug nandrolone phenylpropionate, while still available, was in decline. At that time, nandrolone phenylpropionate had not been abandoned by Organon, partly because of slightly different therapeutic uses in some countries, so it could remain a lucrative market for a while. As the size of the anabolic steroid market continued to grow during the 1970s and 1980s, it attracted the attention of other drug manufacturers, and many drug companies have since begun producing their own versions of nandrolone phenylpropionate. Today, however, the drug is almost nonexistent. The current owner of Organon (Merck/MSD) will be selling nandrolone phenylpropionate and its production (as a branded product) is coming to an end.

Structural features:

Nandrolone phenylpropionate is a modified form of nandrolone in which a carboxylate (phenylpropionate) has been attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids and are absorbed more slowly in the injected area. Once in the bloodstream, the ester is removed to produce free (active) nandrolone. Esterified steroids are designed to prolong the window of therapeutic effect after administration, allowing for less frequent injections compared to injections of free (unesterified) steroids. Nandrolone phenylpropionate reaches peak nandrolone release 24-48 hours after deep intramuscular injection and declines to near baseline levels within a week.

Side effects (estrogen):

Nandrolone has a low estrogen conversion, estimated at only about 20% of testosterone. This is because while the liver can convert nandrolone to estradiol, in other, more active steroid aromatization active sites, such as adipose tissue, nandrolone has much lower estrogen-related side effects than testosterone. However, elevated estrogen levels at high doses can still be noticed and can cause side effects such as increased water intake, increased body fat, and gynecomastia. Therefore, anti-female, anadra file, and exemestane are needed. Can effectively regulate estrogen.

It is worth noting that nandrolone has some progestogenic activity in the body. Although progesterone is a c-19 steroid, removal of this group from 19-norprogesterone yields a hormone with greater binding affinity for its corresponding receptor. Because of this feature, many non-19-anabolic steroids display a certain affinity for the progesterone receptor. Progestogen-related side effects are similar to estrogens, including negative feedback inhibition of testosterone production and increased rates of fat storage. Progesterone also increases the stimulating effect of estrogen on the growth of breast tissue. There seems to be a strong synergy between these two hormones, so gynecomastia may even occur with the help of progesterone, even without excess estrogen levels. The use of an anti-estrogen with an estrogen-suppressing component is usually sufficient to reduce gynecomastia caused by nandrolone.

Side effects (androgenic):

Although classified as an anabolic steroid, the substance can still have androgenic side effects, especially at higher doses. These side effects may include onset of oily skin and body/facial hair growth. Anabolic/androgenic steroids may also worsen male pattern baldness. Women are also warned of the potential pathogenic effects of anabolic/androgenic steroids. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with relatively low androgenic activity relative to its tissue-building effects, making the threshold for androgenic side effects considerably higher compared with androgenic drugs such as testosterone, methyltestosterone, or fluoxymesterone. It is also important to point out that due to its mild androgenic nature and ability to suppress endogenous testosterone, nandrolone tends to interfere with libido in males when another androgen is not used.

Note that in androgen-responsive target tissues such as skin, scalp, and prostate, the relative androgenicity of nandrolone is reduced by reduction to dihydrosolone (DHN). 5-alpha reductase is the main cause of this metabolism. Concomitant use of 5-alpha reductase inhibitors such as finasteride or dutasteride interferes with the site-specificity of action of nandrolone, thus significantly increasing the propensity of nandrolone to produce androgenic side effects. If hypoandrogenicity is desired, reductase inhibitors should be avoided with nandrolone.

Side Effects (Hepatotoxicity):

Nandrolone is not c-17α-alkylated and does not have hepatotoxic effects. Hepatotoxicity is therefore unlikely.

Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may convert HDL to LDL, leading to a greater risk of arteriosclerosis. The relative effects of anabolic/androgenic steroids on serum lipids depend on dose, method of administration (oral vs. parenteral), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Administration of 600 mg nandrolone decanoate weekly for 10 weeks showed a 26% reduction in HDL cholesterol levels. This inhibitory effect was slightly higher than that reported with the same dose of testosterone enanthate, consistent with earlier findings that nandrolone decanoate had a stronger negative effect on HDL/LDL ratios than testosterone propionate. For the effect of serum lipids, nandrolone is significantly weaker than c-17α alkylating agent. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and cause left ventricular hypertrophy.

To help reduce cardiovascular tension, fish oil supplementation (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with similar ingredients are recommended.

Side effects (testosterone suppression):

It will inhibit the production of endogenous testosterone, so PCT is needed.

Use (male):

Usual dosages for physique or performance enhancement purposes are in the range of 200-400mg per week, taken in cycles of 4-8 weeks. This level is sufficient for most users to see measurable gains in lean muscle mass and strength. Note that due to the fast-acting nature of phenylpropionate, the weekly dose is usually divided into two administrations.