Cas No: 32780-32-8
Molecular Formula: C50H68N14O10
Molecular Weight: 1025.2
Purity (HPLC): 98.0%min.
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: about 10% of theoretical
Peptide Content (N%): 80.0% min.
Water Content(Karl Fischer): 6.0%max.
Acetate Content (HPIC): 15.0%max.
Mass Balance: 95.0~105.0%
Appearance: White powder
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Scientists have developed a drug that could boost female sexual desire. Tests in female rats are proving promising, showing "significantly enhanced" sexual behaviour. Its developers believe it could be a more significant development in the treatment of sexual dysfunction.If human trials do prove successful, it could be on the market within three years.The drug, PT141, is being developed by researchers at Concordia University, Montreal, Canada and Palatin Technologies - the company which is developing it. PT141 seems to encourage the female rats to actively seek out the males for sex, which in turn heightens their sexual arousal.The drug, which comes in the form of a nasal spray, has a virtually instantaneous effect. The company is carrying out tests to see if the drug benefits women who have normal sexual function.A study involving men with erectile dysfunction is also underway. Experts in the UK stress research into the drug is still at a very early stage, but say it is hopeful. Currently, the only help available for women with sexual dysfunction problems is psychological or sexual therapy.
PT141 is a copy of a hormone which has an effect on the nervous system called alpha-melanocyte-stimulating hormone. It has been established that melanocyte-receptors in the brain play a part in several behaviours including sexual arousal. So stimulating these receptors using PT141 may stimulate sexual function.
A study of around 40 female rats showed a three- to five-fold increase in solicitations in rats who were given the drug compared to those which were not. Jim Pfaus, professor of psychology at Concordia University, is carrying out the research into PT141's effects on female rats, and he told BBC News Online: "There's nothing in the arsenal now to treat female sexual dysfunction. That's one of the things that's really promising about this drug". "If you have a woman in a loving relationship, but who just doesn't feel desire for sex, the question is why. What goes on to inhibit that?"
He said it could be that there was an interruption in the "chain of command" within the body which leads to desiring sex.
PT-141 in Men:
• eﬀective in a broad range of patients, including those with severe ED and those non-responsive to sildenaﬁl
• eﬃcacy in “at-home” studies is comparable to PDE-5 inhibitors
• up to 50% of ED patients were restored to a normal level of function
• co-administration with sildenaﬁl shows superior eﬃcacy
• side eﬀects include facial ﬂushing, nausea, aftertaste and post-nasal drip
PT-141 in Women:
Palatin conducted a Phase 2A study in 18 premenopausal women with a diagnosis of female sexual
dysfunction (FSD). Patients reported a signiﬁcant increase in sexual desire and in genital arousal after
receiving PT-141, compared to
placebo. Additionally, there was a correlation between sexual desire and genital arousal in patients receiving
PT-141, an observation that further reinforces the potential importance of these reports.
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