Amethocaine Hydrochloride Local Anaesthetic Agents Tetracaine Hydrochloride 94-24-6
Quick Detail of Tetracaine hydrochloride
Introduction:
Product Name: Tetracaine hydrochloride
Synonyms: INTERCAIN HYDROCHLORIDE
CAS: 136-47-0
MF: C15H25ClN2O2
MW: 300.82
EINECS: 205-248-5
mp: 149°C
storage temp: Refrigerator
Appearance: White Solid
General Infomation Of Tetracaine hydrochloride:
Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.
A systematic review investigated tetracaine for use in emergency departments, especially for intravenous cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first-attempt cannulations.
Test Report(COA):
| Test Items |
Specification |
Test Results |
| Appearance |
Fine, white, crystalline, odorless powder |
confirm |
| Identification |
ABC in Pass |
confirm |
| Solubility |
Very soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene |
confirm |
| USP Reference standards |
USP Tetracaine Hydrochloride RS.
USP Endotoxin RS. |
confirm |
| Melting point |
145~150 degree |
146.0~147.5 degree |
| Chromatographic purity |
In Pass |
confirm |
| Related substance |
Not more than the reference solution 0.05% |
confirm |
| Heavy metals |
≤10ppm |
confirm |
| PH |
4.5-6.5 |
5.8 |
| Residue on ignition |
≤0.10% |
0.05% |
| Loss on Drying |
≤ 0.5% |
0.19% |
| Assay |
98.0 -101.0% |
100.1% |
| Conclusion |
Confirms USP 32 |
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