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High Purity 99% Celecoxib Raw Powder For Arthritis Treatment CAS 169590-42-5
Synonyms: CELEBREX;CELECOXIB;4-[[5-(4-METHYLPHENYL)-3-TRIFLUOROMETHYL]-1H-PYRAZOL-YL]BENZENESULFONAMIDE;4-[5-((4-METHYLPHENYL)-3-TRIFLUORPMETHYL)-1H-PYRAZOL-YL]BENENESULFONAMIDE;Celecoxib, 4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamide;Benzenesulfonamide, 4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-;4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide;Celebra
Celecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug. It is used to treat the signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in patients two years or older.
Side effects include a 37% increase in incidence of major vascular events, which include nonfatal myocardial infarction, nonfatal stroke, or death from a blood vessel-related cause.Additionally, an 81% increase in incidence of upper gastrointestinal complications occurs, which include perforations, obstructions, or gastrointestinal bleeding as in all NSAIDs.
Celecoxib is used for osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation, ankylosing spondylitis, and to reduce the number of colon and rectal polyps in people with familial adenomatous polyposis. It may also be used in children with juvenile rheumatoid arthritis who are older than two years of age and weigh more than 10 kg (22 lb).
For postoperative pain, it is more or less equal to ibuprofen. For pain relief, it is similar to paracetamol(acetaminophen). And in osteoarthritis acetaminophen is the first line treatment for OA.
It was originally intended to relieve pain while minimizing the gastrointestinal adverse effects seen with conventional NSAIDs. In practice, its primary use is in people who need regular and long-term pain relief; probably, no advantage exists to using celecoxib for short-term or acute pain relief over conventional NSAIDs, except in the situation where nonselective NSAIDs or aspirin cause cutaneous reactions (urticaria or "hives").
Tentative evidence indicates its use in treating a number of psychiatric disorders, including major depression, bipolar disorder, and schizophrenia.
It has been used to reduce colon and rectal polyps in people with familial adenomatous polyposis, but it is not known if it decreases rates of cancer, so it is not a good choice for this reason.
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which relieves pain and swelling (inflammation). It is used to treat arthritis, acute pain, and menstrual pain and discomfort. The pain and swelling relief provided by this medication helps you perform more of your normal daily activities
Celecoxib works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.
Celecoxib is also sometimes used with surgery and other treatments to reduce the number of polyps (abnormal growths) in the colon (large intestine) and rectum in patients with familial adenomatous polyposis (a condition in which hundreds or thousands of polyps form in the colon and cancer may develop). Talk to your doctor about the risks of using this medication for your condition.
|Appearance||White to off-white crystalline powder|
A.The infrared absorption spectrum should meet with the reference spectrum
B.The retention time of sample major peak should meet with the retention time of reference substance major peak
Any other individual impurity≤0.5%
|Residue On Ignition||≤0.2%|
|English Name||CAS No.|
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