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BP Standard Indometacin Powder For Pain Killer Anti Inflammatory Supplements CAS 53-86-1
Product Name: Indometacin
Melting point 155-162 °C
storage temp. Store at RT
solubility ethanol: 50 mg/mL, clear, yellow-green
pka 4.5(at 25°C)
Water Solubility Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
Sensitive Light Sensitive
Stability: Stable. Incompatible with strong oxidizing agents.
Indomethacin is a kind of stronger corticoid anti-inflammatory and antipyretic and analgesic, by inhibiting cyclooxygenase reducing the synthesis of prostaglandin (PG), to prevent the formation of the nere impulses, inflammation tissue inhibiting inflammatory reaction, including inhibition of leukocyte chemotaxis and lysosomal enzyme release, etc., and produce antipyretic, analgesic and anti-inflammatory effects.
Indomethacin anti-inflammatory, antipyretic effect is very strong, its anti-inflammatory effect is better than bute, 84 times better than hydrocortisone, and sugar cortical hormone, used in combination with aspirin, bute, can reduce their dosage, toxic and side effects, improve curative effect;
Second is antipyretic effect, 10 times than amidopyrine ;its analgesic action is weak , only to the inflammatory pain has obvious analgesic effect, but the effect is good for inflammatory pain than Baotai loose, analgin and salicylic acid.
|Appearance||White or yellow crystalline powder||Conforms|
|Absorption at 318nm||170-190||185.6|
|Loss on drying||≤0.5%||0.07%|
Clinical is mainly used for the salicylic acid, drugs are less tolerance or curative effect is not obvious in the acute and chronic rheumatic or rheumatoid arthritis, ankylosing spondylitis, slippery bursa phlogistic, tenosynovitis, articular capsulitis, osteoarthritis and acute gout and cancerous pain, etc.
In recent years, the researchers try to use indomethacin biliary colic, dysmenorrhea, migraine, glomerulonephritis, polyuria, salmonella gastroenteritis, orthostatic hypotension, bart syndrome and so on, all have good curative effect.
It can also be used to treat eye pigment meningitis, keratitis, scleritis, glaucoma and fever caused by cancer or other difficult to control the fever.
Dermatologist for lupus erythematosus (sle), white plug syndrome, scleroderma, nodular erythema, herpes zoster, joint type of psoriasis, etc. photosensitive dermatitis induced by topical treatment of eczema, allergic dermatitis, and local pain.
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Professional Manufacture: We are legit and professional pharmaceutical manufacturer specialized in steroid hormone powders, steroid
injectable liquids, peptides,pharmaceutical raw materials & its intermediate.Our factory is in Nanhu Shouyi
Industrial District, just by the side of the beautiful South Lake in Wuhan. Our company integrates R&D,
producing, operating and marketing into an organic whole. All products are produced under
GMP conditions according to Standard Operation Procedure(SOP),not from little underground labs or black markets, so the quality is guaranteed. We have authority of export and import, and have experience of export for more than 10 years.
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