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Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5

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Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5

China Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5 supplier
Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5 supplier Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5 supplier

Large Image :  Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5

Product Details:

Place of Origin: China
Brand Name: Biofriend
Certification: ISO9001
Model Number: 42971-09-5

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: USD1-10/g
Packaging Details: stealth package
Delivery Time: 5-8 works day
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 5000kg
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Detailed Product Description
Color: White Appearance: Powder
Product Name: Vinpocetine Assay: 99%
Usage: Cerebrovascular Expansion

Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5

 

 

Quick Details :

Product name: Vinpocetine

Other Name: Eburnamenine-14-carboxylic acid ethyl ester;(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester

Plant Origin: voacanga seed extract

Specification: 99%

CAS NO. : 42971-09-5

Molecular weight: 350.45

Molecular formula: C22H26N2O2

Appearance: light yellow to off-white powder

 

 

Description:


Vinpocetine is a derivative of Vincamine, which is extracted from the Periwinkle plant ( Vinca Minor, Vinca Pervinca ). Research suggests that Vinpocetine helps to maintain healthy blood circulation in the brain and supports certain neurotransmitters in the memory process. Vinpocetine supports and protects brain blood vessel health and aids mental function.

 

(1) Vinpocetine is a cerebrovascular expansion drug and has a relatively stronger function than Vincamine. It can selectively increase cerebral blood flow, enhance and improve brain oxygen supply, promote metabolism, enhance the capacity of deformation for red blood cells, reduce blood viscosity, inhibit platelet aggregation, improve tissue metabolism.
(2) Vinpocetine is mainly used in the treatment of cerebral infarction sequela, cerebral hemorrhage sequelae, cerebral arteriosclerosis, etc. It can also used in the treatment of retinal vascular sclerosis and blood vessel spasm, the elderly deafness, and dizziness.
(3) Vinpocetine is a half synthetic Vincamine derivative, and has the similar effect with Vincamine. It has a stronger expansion function for cerebrovascular selectively.

 

Pharmacological effects are as follows:
Inhibit the activity of calcium dependency phosphodiesterase, increase the content of cAMP which can relax vascular smooth muscle, then relax vascular smooth muscle, and further increase cerebral blood flow. Enhance the capacity of deformation of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and thus improve blood flow and microcirculation. Promote the brain tissue to absorb glucose, and promote the transformation of brain monoamine metabolism. Inhibit the increase of brain lactic acid during cerebral ischemia, increase the ATP content, inhibit the generation of lipid peroxide in the brain, delay the occurring of spasm caused by cerebral ischemia, have the function of improving cerebral metabolism and protecting brain.

 

Application:

 

1)VINPOCETINE is a semisynthetic derivative alkaloid of vincamine, and also can be semisynthesized from tabersonine, an extract from Voacanga Africana Seed.
2)Clinical studies suggest that it facilitates cerebral metabolism by improving cerebral blood flow, increasing glucose and oxygen utilization by neurons and concentration of neurotransmitters involved in the process of memory formation.
3)Clinical studies have also shown that Vinpocetine may help to maintain healthy microcirculation in the inner vital organs of ears and eyes.
4)Research has shown that the effects of this compound go beyond mere prevention and turn it into a Powerful Memory Enhancer.

1. It has vasodilating, blood thinning, and memory-enhancing actions.
2. It acts as a cerebral stimulant and vasodilator.
3. It is used to treat arteriosclerosis.
4. It is very effective in curing dementia caused due to insufficient blood supply to the brain.
5. It interferes with cells' ability to synthesize DNA and RNA.

Vinpocetine is a kind of natural medicine extracted from small vinca flower, and belongs to the indole alkaloids. Can be synthetic now. The mechanism of its pharmacological action is to inhibit the activity of calcium dependency phosphodiesterase, increase the content of CGMP which can relax vascular smooth muscle, then relax vascular smooth muscle, and further increase cerebral blood flow; Enhance the capacity of deformation of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and thus improve blood flow and microcirculation; Promote the brain tissue to absorb glucose, and promote the transformation of brain monoamine metabolism; Inhibit the increase of brain lactic acid during cerebral ischemia, increase the ATP content, increase thedegree of oxygen dissociation in hemoglobin; Increase the resistance capacity for cerebral anoxia and occurring of spasm caused by cerebral ischemia, inhibit the generation of lipid peroxide in the brain. Oral absorption effectively, reach peak at 1 h, then metabolize into Vinpocetine in the body. The half-life of plasma elimination is about 1 hour. For 4 weeks in a row, no accumulation in the body. Clinical used in cerebral infarction sequela, cerebral hemorrhage sequelae, cerebral arteriosclerosis, cerebral vasospasm, brain endarteritis caused vertigo, tinnitus, headache, dizziness, limb numbness, incontinence and other clinical manifestations, depression, anxiety, sleep disorder and other mental symptoms. Clinical experience has shown that it is effective regardless of the length of the course of the disease, and the symptom is fixed or not.

Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5

 

Recommend Dosage :

Take Vinpocetine with meals to enhance absorption.

The standard low dose is 5mg of Vinpocetine at each of these three meals, with 20mg per meal seen as a high dose. This dose range is suitable for the purposes of neuroprotection, enhancing cerebral blood flow, and reducing the rate of cognitive decline.

Side Effects

IV administration of Vinpocetine can cause serious adverse effects, such as death from sudden falls in blood pressure and heart rate (R, R2). However, this is not an issue with oral Vinpocetine at the standard dosages.

There have been reports of skin allergy to vincamine (R).

There was also one report of a sudden drop in white blood cell count at 15mg per day (R).

 

COA of the Vinpocetine:

Items

Specification

Results
appearance White or slightly yellow, crystalline powder White crystalline
Solubility Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrousethanol confirms
Identification (IR)

same wave numbers as that of the Vinpocetine, CRS similarly prepared

CRS similarly prepared.

Conforms
Specific Optical Rotation(On dried basis) Between +127° and +134° +132.7°
Related Substances (External Standard method)
Ethyl vincaminate(A) ≤0.6% Conforms
Apovincamine(B) ≤0.5% Conforms
Methoxyvinpocetine(C) ≤0.3% Not detected
Dihydrovinpocetine(D) ≤ 0.5% Not detected
Other single impurity ≤0.10% Conforms
Total impurity ≤ 1.0% 0.19%

Loss on drying

≤ 0.5% 0.04%

Sulphated ash

≤ 0.1% 0.07%
Assay(On dried basis) 98.5% ~101,5% , 100.2%

 

Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5

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