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|Product Name:||Tianeptine Sodium||Cas:||30123-17-2|
Top Quality Antidepressant Use Tianeptine Sodium Pharmaceutical Raw Powder Cas 30123-17-2
Product name: Tianeptine Sodium Salt
CAS No: 30123-17-2
Packing Customized: package as you require
Appearance: White crystalline powder
Quality Standard: Enterprise Standard
Usage: Treatment of depression.
Tianeptine sodium is primarily used for its mood boosting and anti-anxiety properties. This substance also has nootropic abilities in regards to individuals whose cognition is negatively impacted by mood disorders. It has the ability to improve focus and concentration in individuals who have poor attention spans as well.
Depressive illness devastates millions of lives. Tianeptine is a neuroprotective antidepressant that reverses the neuronal damage and lasting misery caused by chronic, uncontrolled stress. Tianeptine acts both as a non-sedating anti-anxiety agent and a non-stimulating mood-brightener. Uniquely in clinical medicine, tianeptine acts as a selective serotonin reuptake enhancer. Its puzzling efficacy as an antidepressant illustrates how little modern psychiatric medicine really understands about mind, mood and depression.
Tianeptine is chemically a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects. It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas (carbogen) on paroxetine or tianeptine therapy showed equivalent panic-blocking effects. Like many antidepressants (including bupropion, the selective serotonin reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and numerous others) it may also have a beneficial effect on cognition in people with depression-induced cognitive dysfunction.
Tianeptine sodium salt is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).
|Description||White to yellowish powder, very hygroscopic.||Off-white powder, very hygroscopic.|
|Solubility||Freetly soluble In water and methanol and dichloromethane||Complies|
|Identification||(1)By IR, To match with working standard||Complies|
|(2)It gives reaction of sodium||Complies|
|Impurities A||≤0.1%||Not detected|
|Related compounds||Any impurity ≤0.1%||<0.1%|
|Total impurities ≤0.4%||0.25%|
|Residual Solvents||Acetidin≤ 0.5%||Not detected|
|Dichloromethane≤ 0.06%||Not detected|
|Methanol≤ 0.3%||Not detected|
|Acetone ≤ 0.5%||Not detected|
|N, N-dimethylformamide≤0.088%||Not detected|
|Assay||99.0%-101.0%(On anhydrous basis)||99.98%|
|Conclusion||Conform to EP8.0|
Tianeptine Sulfate is excreted much more slowly than Tianeptine Sodium, meaning it remains active within the body for a longer duration.
One of the main downsides to Tianepine Sodium is its ability to clump after exposure to normal conditions.
Tianeptine Sulfate does not absorb moisture from the air, and remains as a powder - making it much easier to work with.
Tianeptine Sodium is not stable in atmospheric moisture, and is very light sensitive, degrading quickly when exposed. Tianeptine Sulfate is much more stable, with much less light degradation.
The taste of Tianeptine Sodium has been described as "bitter" and reportedly "tastes like death".
Tianeptins Sulfate, on the other hand, has very little taste at all.
mproving the brain function
Preventing and treating senile dementia
Enhancing the learning ability
Increasing the attention
Relieving the anxiety
Tianeptine sulphate is an improved salt of Tianeptine.
It is not hygroscopic so handling the powder is a lot easier. Since it is not as readily absorbed and excreted from the body, the sulfate salt allows for a more controlled release of the Tianeptine over longer periods. Rather than having to dose three times with rapid peak effects and rapidly falling effects, the sulfate salt allows for one dose to maintain plasma levels in the body much longer than the sodium salt. These improved characteristics make Tianeptine Sulfate a novel addition.
Based on chemical structure and recent online reviews, the Sulphate form of Tianeptine has a
This is caused, in part, by a slower rate of absorption.
Unlike Tianeptine Sodium, the Sulphate form is not hygroscopic, meaning itdoes not absorb moisture from the air.
Furthermore, it is more stable when exposed to light.
From the preliminary online discussions, Tianeptine Sulphate is preferred among users.
It is likely to replace Tianeptine Sodium in time, due to favorable pharmacodynamics.
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