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|Appearance:||White Crystalline Powder.||CAS No:||131707-23-8|
CAS No. : 131707-23-8
Appearance :Off-white powder
Molecular formula :C22H25BrN2O3S.HCl
Storage at -20°C 2 years
Arbidol is a kind of double-effect anti-influenza various drug developed by the research center of the chemical drug (former Soviet) and can simultaneously fight against the influenza caused by both influenza virus A and B while may also have antiviral activity against other kinds of certain respiratory viral infections. It has been first approved for entering into market in 1993 in Russia for the control of influenza s well as other acute respiratory viral infections.
According to the different antigen, influenza viruses are divided into A, B, C three types. Because the variation of the influenza virus is relative fast, so humans can’t get long-lasting immunity. For the treatment of influenza, clinically people majorly focus on treating symptoms and preventing secondary infection while being lack of therapeutic agent for targeting the cause of disease. There are three major research directions at home and abroad: vaccines, interferon and anti-viral chemotherapy. The volatility of an influenza virus antigen and the multiplicity of the acute respiratory viral infections have imposed insurmountable obstacles for the vaccines development. Moreover, interferon, due to various reasons including source, dosage and side effects, has been limited in the application of the prevention and treatment of influenza. Therefore, the development of antiviral chemotherapy is an important direction for prevention and treatment of influenza.
Currently, clinical used antiviral chemotherapy drugs only include three kinds: ribavirin, amantadine and rimantadine. Among them, ribavirin, although has antiviral activity on influenza virus A and B at high doses but have teratogenic and mutagenic toxicity like nucleoside drugs and can cause anemia and immune suppression while amantadine and rimantadine are only effective in treating influenza A and is easy to cause central nervous system toxicity, thereby reducing the clinical value.
Arbidol hydrochloride, compared with other antiviral drugs, has the following eight characteristics:
1, it is capable of killing both influenza virus A and B at the same time.
2, it can prevent the viral integration and replication.
3, it can induce the generation of interferon and significantly improve the immunity of human body.
4, it can significantly reduce the flu symptoms and shorten the duration of flu.
5, it can prevent the occurrence and post-development of influenza syndrome.
6, administration of it can effective prevent the influenza upon the pandemic of flu.
7, in vitro tests have demonstrated that it is effective in treating both SARS virus and avian influenza virus.
8, it is convenient for oral administration with high safety and good compliance.
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