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It was first discovered in the muscle by Goldspink, et al. In human muscle, a 49-base insert changes the reading frame in mechano Hormone(MGF) as compared. When mechanical overload is introduced to a muscle (as by weight training), the gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly (called the MGF splice variant 1).
This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue.The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing into MGF, production then switches towards producing a systemic release of 1Ea from the liver, which also upregulates protein synthesis as well.
The expression splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary anabolic mechanism by which the body produces new muscle.MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.
PEG MGF Doses and Usage:
Using PEG MGF on cycle or off cycle, you are going to experience recovery that is far superior to any generic peptide available. Just like normal peptides, remember that PEG MGF comes in the form of a white delicate powder that needs to be reconstituted with bacteriostatic water and kept in the refrigerator.
PEG MGF does not need to be systematically administered because of its long half-life (several days). It will circulate your body binding to the receptors where muscle tissue damage has taken place. Administration should be timed post workout or on recovery days when you plan on resting.
Rest days are the best way to get the most use out of PEG MGF, as you will have lower level of IGF-1 and the long lasting PEG MGF will have the ability to run the course of the body while you focus on recovery.
I have personally ran PEG MGF and administered into the quad regions after very long sessions where my quads were ripped to shreds. The recovery time and muscle growth in those areas was noticed after one week of use.
Duly noted was the recovery time after a 100+ mile ride. On the recovery day, I administered 200mcg of PEG MGF and rested. The following day muscles felt recovered and soreness was not present for the next training ride.
An insulin syringe needs to be used to inject subcutaneously or intramuscularly with a dose around 200-400mcg. Bilateral dosing can be used, but a single site administration will work just as well.
PEG MGF Benefits:
When your muscle is damaged, your body releases a pulse of an MGF splice variant as I outlined above, followed by a less anabolic longer acting version from the liver. Therefore, it seems a waste to inject MGF at this time as you will just blunt your body's own release, your not enhancing it.
So using PEG MGF on non workout days is actually the best route. Since the muscle has been damaged, there are plenty of receptors for MGF, and the effects are systematic. All muscles will be aided in recovery through increased nitrogen retention, protein turnover, and satellite cell activation.
Recovery is just going to sky rocket. Doing this means you're increasing the length of your body's own mechanism for muscle repair and growth, and you're opening up the anabolic window.
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