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Aromatase Inactivator Antiestrogen Steroid 107868-30-4 Aromasin/Exemestane for Breast Cancer Treatment
Exemestane is a steroidal antiestrogen and irreversible aromatase inhibitor. Exemestane acts as a false substrate for the aromatase enzyme. Exemestane also prevents the conversion of androgens to estrogens and is used to treat estrogen-dependent breast cancer.
Exemestane is a drug used to treat breast cancer in post-menopausal women (women who have gone through the menopause/change of life). Given as a tablet, it is a type of hormone treatment (also referred to as endocrine therapy) and belongs to a group of drugs called aromatase inhibitors.Men with breast cancer may also be given exemestane, usually alongside drugs that suppress hormone production from the
testes. However, tamoxifen is usually the first treatment of choice
Chemical Name: 6-Methylenandrosta-1,4-diene-3,17-dione
Alias: Aromasin ; Exemestan; Exemestance , Exalamide, ExeMestine , 6-Methyleneandrosta-1 , 4-Diene-3 ,17-Dione
Product content: 99%min
CAS Number: 107868-30-4
Molecular formula: C20H24O2
Molecular Weight: 296.40
Packing specifications: 25kg / barrel
Molecular weight: 296.4
Appearance: White or Almost White Crystalline Powder
Usage: the third generation aromatase inhibitors, used in the treatment of metastatic breast cancer and used as aid in the treatment of early breast cancer.
|Description||: White Crystalline Powder||White Powder|
|Assay(by HPLC)||: 98.0~102.0%||98.64%|
|Melting Point||: 191~195°C||193.5~195.0°C|
|Loss On Drying||: 0.5%max||0.19%|
|Specific Rotation||: +288°~ +298°||+290.2°|
|Residue On Ignition||: 0.1%max||0.03%|
|Related Substances||: Total:1.5%max||<1.3%|
|Residue Solvents||: 0.2%max||0.10%|
|Heavy Metals||: 20PPm max||<10PPm|
|Conclusion||The specification conform with enterprise standard.|
High Purity Exemestane/Aromasin/Exemestan/CAS No: 107868-30-4
the third generation aromatase inhibitors, used in the treatment of metastatic breast cancer and used as aid in the treatment of early breast cancer.
Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive and can be treated with drugs that block the effects of these hormones.
In women who have had their menopause, oestrogen is mainly produced by changing androgens (sex hormones produced by the adrenal glands) into oestrogens. This process is called aromatisation and happens mainly in the fatty tissues, muscle and the skin. It needs a particular enzyme called aromatase.
Exemestane blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.
Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. For example, the hormone testosterone made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair. The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells. Hormone therapies work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell. The different types of hormone therapies are categorized by their function and/or the type of hormone that is affected.
Exemestane is an aromatase inhibitor. This means it blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink.
Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.
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