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|MW:||479.03524||Loss On Drying:||≤0.50%|
|Residue On Ignition:||≤0.10%||Specific Rotation:||+39°~ +43°|
White Powder Body Builder Sarms Steroids MK-677 Ibutamoren selective androgen receptor modulators
2-Amino-N-((R)-2-(benzyloxy)-1-((1-(methylsulfonyl)spiro(indoline-3,4'-piperidin)-1'-yl)carbonyl)ethyl)-2-methyl-propionamide monomethanesulfonate;2-Amino-N-((R)-2-(benzyloxy)-1-((1-(methylsulfonyl)spiro(indoline-3,4'-piperidin)-1'-yl)carbonyl)ethyl)-2-methylpropionamide monomethanesulfonate;Crescendo;MK-0677;UNII-R90JB6QJ2B;Propanamide, 2-amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methyl-, (R)-, monomethanesulfonate;
868.9°C at 760 mmHg
|Desiccate at RT|
Intermediates and Fine Chemicals;Pharmaceutical compounds;Inhibitor; Revatio
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An orally active selective type 5 cGMP phosphodiesterase inhibitor. pharmaceutical material
Nutrobal (Mk-677) is an orally administrated growth hormones secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormones. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormones Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
How MK 677 Works:
Produced by Reverse Pharmacology, MK 677 (Nutrobal) is an orally administered growth hormone secretagogue that is designed to stimulate the pituitary gland to release growth hormones. In case you're wondering, "secretagogue" is basically a natural substance that causes another substance to be secreted, such as gastrin.
MK 677 (Nutrobal) was originally formulated to keep health problems like osteoporosis, obesity and muscle wasting, but has been seen to promote an increase in lean body mass as well as a boost in IGF-1 serum concentration during clinical runs.
Moreover, here are the positive effects of MK 677 (Nutrobal) in terms of improving growth hormone pulse intensity:
Inhibits the signaling of somatostatin receptors.
Slows down the activity of somastostatin in the system.
Improves somatotroph signaling in growth hormone releasing hormones (GHRH).
Amplifies and increases the overall production and release of GHRH.
MK-677 is a medicine which acts as a potent, orally active growth hormones secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormones and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormones deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.
SARMS dosage and usage:
Andarine,S4, Acetamidoxolutamide: 50-75mg total per day
MK-2866 (Ostarine, OSTA-SARMS): 2.5-50mg per day
GW-50, GW-501516, Cardarine, GSK-516: 20mg per day
MK-677 (Nutrobal): 25mg a day
LGD-4033 (Anabolicum): 10mg per day (2mg per day and up to 20mg)
RAD-140: 20-30 milligrams (mg) per day
SR-9009: 20-30mg per day.
|Characteristics||White to yellowish-white crystalline powder||conform|
|Melting point||32 ~ 37ºC||33~36ºC|
|Specific optical rotation||+77°~+82°||+79.3°|
|Loss on drying||≤0.5%||0.15%|
|Assay||97 ~ 103%||99.08%|
|Free heptanoic acid||≤0.2 %||0.10%|
|Residual solvents(GC)||Methanol ≤100ppm||Pass|
Supply SARMs and others:
Ostarine,MK-2866, Enobosarm 841205-47-8,1202044-20-9
Andarine (S-4) 401900-40-1
Andarine (GTX-007) 401900-40-1
MK-677, Ibutamoren, 159752-10-0
Contact Person: Corleone