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Smarter Nootropics Antidepressant Nsi-189 Pharmaceutical Drugs Inhibitors Cas 1270138-40-3

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Smarter Nootropics Antidepressant Nsi-189 Pharmaceutical Drugs Inhibitors Cas 1270138-40-3

Smarter Nootropics Antidepressant Nsi-189 Pharmaceutical Drugs Inhibitors Cas 1270138-40-3
Smarter Nootropics Antidepressant Nsi-189 Pharmaceutical Drugs Inhibitors Cas 1270138-40-3 Smarter Nootropics Antidepressant Nsi-189 Pharmaceutical Drugs Inhibitors Cas 1270138-40-3

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Product Details:
Place of Origin: China
Brand Name: Excellentbiotech
Certification: ISO9001
Model Number: 1270138-40-3
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: USD1-10/g
Packaging Details: stealth package
Delivery Time: 5-8 works day
Payment Terms: T/T, , ,Bitcoin
Supply Ability: 5000kg
Detailed Product Description
Color: White Appearance: Powder
Product Name: Nsi-189 Cas: 1270138-40-3
Assay: 99% Usage: Smarter Nootropics Antidepressant
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Smarter Nootropics Antidepressant Nsi-189 Pharmaceutical Drugs Inhibitors Cas 1270138-40-3



Basic Info.


Product Name: NSI-189
Synonyms: NSI-189;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone NSI189;NSI-189 [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;NSI-189, >=98%;(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]
CAS: 1270138-40-3
MF: C22H30N4O
MW: 366.4998
Product Categories: Inhibitors

Smarter Nootropics Antidepressant Nsi-189 Pharmaceutical Drugs Inhibitors Cas 1270138-40-3 0


PRL-8-53​ Product Description


NSI-189 Phosphate is an orally active novel molecular entity (benzylpiperazine-aminopyridine) that stimulates neurogenesis of human hippocampus-derived neural stem cells. Neurogenesis is believed to play an important part in learning, memory, emotion, stress, depression and other conditions.


According to the World Health Organization (WHO), approx. 300 million people around the world suffer from depression [1]. Aside from genetics or psychological trauma, there are many factors that increase the risk of developing depression such as blood relatives with a history of depression, low self-esteem, sexual orientation, drug abuse, health condition, compulsive disorders and more. Today many also believe that stress can increase the chances to suffer depression because hippocampal cells are sensitive to stress which can lead to decreased neurogenesis, thus neurogenesis may be strongly linked to MDD. The symptoms of depression cause stress where sometimes the affected may not even notice, which creates a vicious cycle potentially worsening the condition.


An increase in serotonin in the brain suppresses the corticotropin-releasing hormone (CRH), a peptide hormone, secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. The repression of CRH causes a decrease in neurogenesis. This is why typical antidepressants are selective serotonin reuptake inhibitors (SSRIs) [4] and their efficacy may be correlated to neurogenesis.


NSI-189 Phosphate Benefits


As mentioned above, the potential benefits of NSI-189 phosphate are:


1. Improvement in behavioral responses associated with depression.
2. Reversal of hippocampal atrophy.
3. May enhance memory and cognition through increase neurogenesis, particularly in depressed subjects.
4. Positive effects may persist after treatment ceases.


How NSI-189 works


This drug was developed to address three important aspects of depression including hippocampal volume, neurogenesis and neurotransmission. NSI-189 increases the volume within the hippocampus. In so doing, hippocampal volume and healthy brain cell density is increased thereby improving mod and cognitive performance. Aside from increasing hippocampal volume, the drug also improves neuronal cell functionality. It works it promoting healthy neuronal cell growth whilst repair damaged areas in the brain.


Dosage and Suggestion


Studies conducted to evaluate effects of NSI-189 revealed that 40 to 80 mg daily is effective in treating depression and cognitive symptoms amongst healthy patients. In these trials, there are no serious adverse events recorded.
Generally, NSI-189 is well tolerated and safe for human use.

Smarter Nootropics Antidepressant Nsi-189 Pharmaceutical Drugs Inhibitors Cas 1270138-40-3 1




Items of Analysis Requirements Results
Appearance Off-white to white powder Conforms
Loss on drying ≤1.0% 0.6%
Heavy metal ≤10ppm Conforms
Water ≤0.5% 0.3%
Purity(HPLC) ≥99% 99.47%
Residue on ingnition ≤0.3% 0.05%
Conclusion The product conforms to in House Standard
Packing Pack in two layers plastic-bag.
Storage Store in a well-closed place with constant low temperature and no direct sun light.
Shelf life 2 years when properly stored.


Major Function


1) Enhance cognition and memory formation.

2) Anxiolytic properties.

3) Anti-depressive effect .
4) Treatment of Alzheimer's and Parkinson's disease.
5) Increase coordination.
6) Improves mood.
7) Help fight fatigue.

8) Prevent oxidation within the brain.
9) Treat alcohol related brain damage.

Smarter Nootropics Antidepressant Nsi-189 Pharmaceutical Drugs Inhibitors Cas 1270138-40-3 2


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Oxiracetam 62613-82-5
Phenibut 1078-21-3
Piracetam 7491-74-9
Pramiracetam 68497-62-1
Aniracetam 72432-10-1
Coluracetam 135463-81-9
Idebenone 58186-27-9
Nefiracetam 77191-36-7
Sulbutiamine 3286-46-2
Melatonine 73-31-4
Sunifiram 314728-85-3
5-Hydroxytryptophan 56-69-9
Tianeptin 66981-73-5
PRL-8-53 51352-87-5
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