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|Product Name:||Avanafil||Assay:||99% Min.|
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Synonyms: (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine;4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;Avanafil;Avanafil (usan/inn);D03217;4-[[(3-Chloro-4-Methoxyphenyl)Methyl] aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;(S)-4-((3-Chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide
Assay: 99% min.
Character: White to Off-White Cyrstalline Solid.
Usage: Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.
Categories: Active Pharmaceutical Ingredients; Cnbio; Erectile Dysfunction; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; API's.
Certificates:SGS,ISO 9001, GMP
Provide Samples: Yes.
Delivery time: Within 8 hours upon receipt of payment
Payment method: T/T,, , bitcoins, bank transfer
Price: Factory price(Negociable)
Packing: Discreet and Disguised packing to pass the customs.
Delivery methods: EMS, DHL, TNT, FedEx, UPS,etc door to door.
Standard: GMP Enterprise standard.
The min. order is 10 grams.
Storage: Shading, Confined Preservation
Usage:Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by FDA on April 27, 2014, and by EMA on June 21, 2015. Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are tadalafil and vardenafil. The advantage of avanafil is that it has the very fast onset of action compared with other PDE5 inhibitors.It is absorbed quickly. reaching a maximum concentration in about 30-45 minutes. About two-thirds of the participants were able to engage in sexual activity within 15 minutes.
It is a development of the phosphodiesterase type 5 inhibitors, for the treatment of male sexual dysfunction, at present in the America, EU and Japan have completed phase II clinical trials, phase III clinical trials will start. The product is composed of Japanese Tanabe Pharma Company and VIVUS company development. In addition to oral dosage forms, VIVUS company is also developing Avanafil urethral administration, for not responding to oral dosage forms of patients.
Avanafil is a potent, highly selective phosphodiesterase 5 inhibitor, in vitro experiments showed that the selectivity of phosphodiesterase 5 stronger than . The compound dear compliance weak against other phosphodiesterase, and effect of adenosine receptor decreased, suggesting that the cardiovascular effects of avanafil should be weaker than .
Pre clinical study showed that avanafil and organic nitrate drugs taken in combination to reduce its on blood pressure was significantly weaker than and nitrate drugs with clothes. Moreover, avanafil inhibition of phosphodiesterase 6 is very weak, the relevant visual disturbance suppression may the enzyme phosphodiesterase 5 inhibitor induced and other.
The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about 30-45 minutes.About two-thirds of the participants were able to engage in sexual activity within 15 minutes.
1. High purity and good quality
2. Professional and discreet packing
3. Fast delivery
4. High success rate to pass customs
(1) High passing rate.
Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed.
(2) Factory Supply, Save intermediate cost, so our price is competitive and parcel can be sent out in 24 hours after payment. Tracking number is available.
(3) We have clients throughout the world.
Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
(4) Good service.
Tell the package update ASAP, and will try best solve when customer encountered various problems.
(5) Discount is possible if order is enough.
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