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|Product Name:||Anastrozole||Alias:||Anastrozole Arimidex|
|Assay:||98%||Appearance:||White Crystalline Powder|
anti estrogen supplements,
anti estrogen medication
CAS 120511-73-1 Anti Estrogen Steroids White Powder Anastrozole Aromasin Powder SERM Aromasin Powder
Arimidex (generic name is anastrozole) is a newer drug developed for the treatment of advanced breast cancer in women. It is manufactured by Zenica Pharmaceuticals and was approved for use in the United States at the end of December 1995. Specifically, Arimidex is the first in a new class of third-generation selective oral aromatase inhibitors.. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression of such a disease can be halted. This is the basic premise behind Nolvadex, except this drug blocks the action and not production of estrogen. The effects of Arimidex can be quite dramatic to say the least. A daily dose of one tablet (1 mg) can produce estrogen suppression greater than 80 % in treated patients. With the powerful effect this drug has on hormone levels, it is only to be used (clinically) by post-menopausal women whose disease has progressed following treatment with Nolvadex (tamoxifen citrate). Side effects like hot flushes and hair thinning can be present, and would no doubt be much more severe in pre-menopausal patients.
There are some concerns with using an aromatase inhibitor such as this during prolonged steroid treatment however. While it will effectively reduce estrogenic side effects, it will also block the beneficial properties of estrogen from becoming apparent (namely its effect on cholesterol values). Studies have clearly shown that when an aromatase inhibitor is used in conjunction with a steroid such as testosterone, suppression of HDL (good) cholesterol becomes much more pronounced. Apparently estrogen plays a role in minimizing the negative impact of steroid use. Since the estrogen receptor antagonist Nolvadex is shown not to display an anti-estrogenic effect on cholesterol values, it is certainly the preferred from of estrogen maintenance for those concerned with cardiovascular health.
Arimidex has another principle drawback, namely the great price of this drug. Tablets can easily sell for $10 each, becoming quite costly with regular use. Clearly the price of an ancillary drug can be much greater than the steroids themselves, a situation destined not to be popular with recreational bodybuilders. Competitors on the other hand are likely to welcome this item. It can ward off the side effects of strong androgen therapy much better than Nolvadex and/or Proviron, making heavy cycles much more comfortable. As the number of countries manufacturing this drug increases, we may be able to look forward to a reduction in price. Privately compounded versions of “liquid Arimidex” have also been formulated “for research purposes” are also available. Generic tabs are also available and these two forms represent a very cost-effective alternative for buying the brand name drug.
Treating certain types of breast cancer in women who have been through menopause, including women with disease progression after tamoxifen therapy. It may also be used for other conditions as determined by your doctor.
Anastrozole is an aromatase inhibitor. It works by lowering blood estradiol concentrations, which may decrease the size and growth of the tumor.
Arimidex can be referred to as an aromatase inhibitor which helps prevent estrogen production in females. Research has shown that the estrogen hormone is responsible for the creation of breast cancer tumors in women. Arimidex is the drug administered to intercept the enzyme aromatase, which is a substance that assists the body tissues in producing estrogen. Arimidex is a popular drug in the battle against breast cancer. It is by and large, a hormonal treatment which can prevent the recurrence of breast cancer. Arimidex, also known as Anastrozole is not a steroid.
Arimidex is known to have diminished estrogen way too much in some patients. This is why blood tests or salivary tests are recommended after a week of usage to determine whether the dosage is appropriate.
Arimidex tends to work quite differently than the traditional anti-estrogens. Anti-estrogens like Clomid or Nolvadex tend to intercept estrogen receptors in certain tissues while activating them in others. Meanwhile, Arimidex directly intercepts the enzyme aromatase. When a patient has been recommended the use of Arimidex, Clomid use along with is unnecessary. Doing so may have some benefits.
Arimidex is generally used for all stages and forms of breast cancer which are classified to be estrogen receptor positive. In case the patient has estrogen receptor negative or triple negative cancer, the usage of Arimidex is unlikely to help.
How does Anastrozole/Arimidex work ?
Arimidex generally works by blocking the aromatoze enzymes, facilitating the decrease in the production of estrogen in the human body. With the decrease in production of Arimidex, the risk of exposure to breast cancer is eliminated. This procedure of treating breast cancer is known as hormonal therapy.
Dosages of arimidex will vary from person to person. This is why blood work is essential to finding the perfect balance. One should start out at half a mg every other day and adjust as needed for the cycle. Some AAS users will not use an AI at first but they will have it on hand just in case. This isn’t always a good idea, as once you start noticing gyno or excessive water weight it could be too late to reverse. Since AAS will continue building in the body and aromatize (steroids turning into estrogen), taking arimidex at this point would be like trying to stop a car already in motion.
General dosages for men: 0.5mgs per day or every other day. Remember, it’s steroid dose dependent.
COA and HPLC:
|Appearance||White crystalline powder|
Conform with standard IR
Conform with standard HPLC
|Solubility||Freely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrile||Complies|
|Total Unspecified Impurity||max. 0.2%||0.07%|
|Individual unspecified impurlty||max. 0.1%||0.04%|
|Related compound B||max. 0.2%||0.06%|
|Related compound C||max. 0.2%||0.04%|
|Related compound D||max. 0.1%||0.05%|
|Related compound E||max. 0.1%||0.05%|
|Limit of cyclohexane||max. 0.08%||ND|
|Limit of ethylacetate||max. 0.1%||0.07%|
|Residue on ignition||max. 0.1%||0.07%|
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